Abstract
A size and shape tuned, multifunctional metal chalcogenide, Cu2S-based nanotheranostic agent is developed for trimodal imaging and multimodal therapeutics against brain cancer cells. This theranostic agent was highly efficient in optical, photoacoustic and X-ray contrast imaging systems. The folate targeted NIR-responsive photothermal ablation in synergism with the chemotherapeutic action of doxorubicin proved to be a rapid precision guided cancer-killing module. The multi-stimuli, i.e., pH-, thermo- and photo-responsive drug release behavior of the nanoconjugates opens up a wider corridor for on-demand triggered drug administration. The simple synthesis protocol, combined with the multitudes of interesting features packed into a single nanoformulation, clearly demonstrates the competing role of this Cu2S nanosystem in future cancer treatment strategies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / chemistry
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Contrast Media / chemical synthesis
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Copper / chemistry*
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Copper / radiation effects
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Delayed-Action Preparations / chemical synthesis*
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Doxorubicin / administration & dosage
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Doxorubicin / chemistry
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Elasticity Imaging Techniques / methods
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Hydrogen-Ion Concentration
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Light
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Metal Nanoparticles / chemistry*
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Metal Nanoparticles / radiation effects
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Metal Nanoparticles / ultrastructure
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Microscopy, Fluorescence / methods
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Multimodal Imaging / methods*
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Nanocapsules / chemistry*
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Nanocapsules / radiation effects
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Nanocapsules / ultrastructure
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Photochemotherapy / methods*
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Theranostic Nanomedicine / methods
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Tomography, X-Ray Computed / methods
Substances
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Antineoplastic Agents
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Contrast Media
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Delayed-Action Preparations
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Nanocapsules
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Copper
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Doxorubicin
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cupric sulfide