Voriconazole-associated visual disturbances and hallucinations

Cutan Ocul Toxicol. 2016 Mar;35(1):80-2. doi: 10.3109/15569527.2015.1020544. Epub 2015 Mar 23.

Abstract

Voriconazole is a second-generation azole widely used for the prevention and treatment of fungal infection in leukemia patients. Voriconazole is considered the primary antifungal agent for invasive aspergillosis. We report a case of 16-year-old girl who developed visual disturbance and visual and auditory hallucinations after intravenous voriconazole treatment for invasive pulmonary aspergillosis. Due to the visual hallucinations and visual disturbance began acutely and shortly after the initiation of voriconazole, and no other cause could be determined, the symptoms were considered to be the side effects of voriconazole. Simultaneous development of visual side effects and hallucinations rarely have been reported before.

Keywords: Color discrimination; hallucinations; visual disturbance; voriconazole.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antifungal Agents / adverse effects*
  • Antifungal Agents / therapeutic use
  • Aspergillosis / drug therapy
  • Female
  • Hallucinations / chemically induced*
  • Humans
  • Vision Disorders / chemically induced*
  • Voriconazole / adverse effects*
  • Voriconazole / therapeutic use

Substances

  • Antifungal Agents
  • Voriconazole