High prevalence of bla(NDM-1) carbapenemase-encoding gene and 16S rRNA armA methyltransferase gene among Acinetobacter baumannii clinical Isolates in Egypt

Antimicrob Agents Chemother. 2015;59(6):3602-5. doi: 10.1128/AAC.04412-14. Epub 2015 Mar 23.

Abstract

The main objective of this study was to decipher the molecular mechanism of resistance to carbapenems and aminoglycosides in a large series of 150 Acinetobacter baumannii clinical isolates collected from July 2012 to September 2013 in Egypt. We report for the first time the emergence of bla(NDM-1) and the cooccurrence of 16S rRNA methylase armA with bla(NDM-1) and bla(OXA-23) in Egyptian hospitals. Multilocus sequence typing identified 27 distinct sequence types, 11 of which were novel.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter baumannii / genetics*
  • Egypt
  • Methyltransferases / genetics
  • Multilocus Sequence Typing
  • RNA, Ribosomal, 16S / genetics*
  • beta-Lactamases / genetics*

Substances

  • RNA, Ribosomal, 16S
  • Methyltransferases
  • beta-Lactamases
  • beta-lactamase NDM-1