Abstract
Between April 1981 and May 1984, 61 patients with advanced diffuse large-cell lymphoma completed treatment with MACOP-B (methotrexate with leucovorin rescue, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin), an innovative pilot chemotherapy program emphasizing weekly treatment, antibiotic prophylaxis, daily corticosteroid treatments, and brief duration (12 weeks). Fifty-one patients (84%) achieved a complete response and 10 patients (16%) had a partial response. Over a median follow-up after treatment of 23 months, the actuarial overall survival for the entire group has been 76%; for complete responders the relapse-free survival has been 90%. Toxicity was modest with one treatment-related death and seven episodes of serious infection. The most frequent toxicity was mucositis. Thus, MACOP-B is an effective treatment for large-cell lymphoma that can be delivered in 12 weeks with an acceptable incidence of toxicity. This regimen can achieve results similar and possibly superior to those of other presently used regimens of longer duration.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Actuarial Analysis
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Adult
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Age Factors
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Aged
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Arachnoid
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Bleomycin / adverse effects
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Bleomycin / therapeutic use
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Bone Marrow / pathology
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Cyclophosphamide / adverse effects
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Cyclophosphamide / therapeutic use
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Doxorubicin / adverse effects
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Doxorubicin / therapeutic use
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Drug Administration Schedule
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Female
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Humans
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Inflammation / chemically induced
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Leucovorin / adverse effects
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Leucovorin / therapeutic use
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Lymphoma, Large B-Cell, Diffuse / drug therapy*
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Lymphoma, Large B-Cell, Diffuse / pathology
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Lymphoma, Large B-Cell, Diffuse / secondary
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Male
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Meningeal Neoplasms / secondary
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Methotrexate / adverse effects
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Methotrexate / therapeutic use
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Middle Aged
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Mucous Membrane / drug effects
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Neoplasm Staging
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Pia Mater
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Prednisone / adverse effects
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Prednisone / therapeutic use
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Vincristine / adverse effects
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Vincristine / therapeutic use
Substances
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Bleomycin
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Leucovorin
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Prednisone
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Methotrexate