Ciliary vesicle formation: a prelude to ciliogenesis

Laura E Yee; Jeremy F Reiter

doi:10.1016/j.devcel.2015.03.012

Ciliary vesicle formation: a prelude to ciliogenesis

Dev Cell. 2015 Mar 23;32(6):665-6. doi: 10.1016/j.devcel.2015.03.012.

Authors

Laura E Yee¹, Jeremy F Reiter²

Affiliations

¹ Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: [email protected].
² Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: [email protected].

Abstract

Reporting recently in Nature Cell Biology, Lu et al. (2015) identify two Eps15-homology-domain-containing proteins as critical effectors of ciliary vesicle formation, an early event in ciliogenesis. Functional dissection reveals that one of them works to convert small vesicles associated with mother centriole distal appendages into a larger ciliary vesicle.

Publication types

Comment

MeSH terms

Animals
Carrier Proteins / genetics*
Cilia / metabolism*
Epithelial Cells / metabolism*
Gene Expression Regulation, Developmental*
Humans
Transport Vesicles / metabolism*
Vesicular Transport Proteins / genetics*

Substances

Carrier Proteins
Vesicular Transport Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding