Health status and quality of life in tuberculosis

James Brown; Santino Capocci; Colette Smith; Steve Morris; Ibrahim Abubakar; Marc Lipman

doi:10.1016/j.ijid.2014.12.045

Health status and quality of life in tuberculosis

Int J Infect Dis. 2015 Mar:32:68-75. doi: 10.1016/j.ijid.2014.12.045.

Authors

James Brown¹, Santino Capocci², Colette Smith³, Steve Morris⁴, Ibrahim Abubakar⁵, Marc Lipman²

Affiliations

¹ Centre for Respiratory Medicine, Royal Free London NHS Foundation Trust, London, and Division of Medicine, University College London, Pond Street, London NW3 2QG, UK. Electronic address: [email protected].
² Centre for Respiratory Medicine, Royal Free London NHS Foundation Trust, London, and Division of Medicine, University College London, Pond Street, London NW3 2QG, UK.
³ Research Department of Infection and Population Health, University College London, London, UK.
⁴ Department of Applied Health Research, University College London, London, UK.
⁵ Research Department of Infection and Population Health, University College London, London, and Medical Research Council Clinical Trials Unit, London, UK.

PMID: 25809759
DOI: 10.1016/j.ijid.2014.12.045

Abstract

Tuberculosis (TB) is a leading cause of global morbidity, yet there is limited information regarding its impact on quality of life and health status. This is surprising given the implications for patient care, the evaluation of novel treatments or preventative strategies, and also health policy. Furthermore, there is no validated TB-specific instrument that measures health status, and thus a wide and non-standardized range of assessment tools have been employed. The studies to date have chosen a number of different comparator populations, and in many TB endemic areas there is a lack of normative data regarding the health status of the general population. Systematic evaluations of quality of life are urgently needed in specific groups, including those with extrapulmonary TB, drug-resistant disease, HIV co-infection, and latent TB infection, and in children with TB; the assessment of post-treatment disability is also required.

Keywords: Health economics; Health status; Measures of health; Quality of life; Tuberculosis.

Publication types

Review

MeSH terms

Adult
Child
Coinfection
Female
HIV Infections / complications
Health Status*
Humans
Morbidity
Quality of Life*
Tuberculosis / complications
Tuberculosis / diagnosis*
Tuberculosis / therapy

Grants and funding

SRF-2011-04-001/DH_/Department of Health/United Kingdom