Sesquiterpene coumarins from seeds of Ferula sinkiangensis

Fitoterapia. 2015 Jun:103:222-6. doi: 10.1016/j.fitote.2015.03.022. Epub 2015 Mar 27.

Abstract

A new sesquiterpene coumarin with a novel sesquiterpene carbon framework, Sinkiangenorin D, and ten known sesquiterpene coumarins were isolated from the seeds of Ferula sinkiangensis. The structures of these compounds, including the relative stereochemistry, were elucidated on the basis of spectroscopic data. All of the isolated compounds were tested against the AGS, HeLa, and K562 human cancer cell lines and showed cytotoxic activities with 50% inhibitory concentration values between 12.7 and 226.6 μM.

Keywords: Colladonin (PubChem CID: 375430); Cytotoxic activities; Episamarcandin; Farnesiferl C (PubChem CID: 15559239); Feklone; Fekrynol; Ferula sinkiangensis; Feselol (PubChem CID: 17977); Lehmannolol; Lehmannolone; Sesquiterpene; Sesquiterpene coumarin; Sinkianone; Umbelliprenin (PubChem CID: 1781413).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Coumarins / pharmacology*
  • Ferula / chemistry*
  • HeLa Cells
  • Humans
  • K562 Cells
  • Molecular Structure
  • Seeds / chemistry*
  • Sesquiterpenes / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Coumarins
  • Sesquiterpenes
  • sinkiangenorin D
  • coumarin