Asymmetrical dimethylarginine promotes the senescence of human skin fibroblasts via the activation of a reactive oxygen species-p38 MAPK-microRNA-138 pathway

J Dermatol Sci. 2015 May;78(2):161-4. doi: 10.1016/j.jdermsci.2015.02.019. Epub 2015 Mar 9.

Authors

Ben Wang¹, Hong-Fu Xie¹, Wen-Zhi Li², Ying-Xue Huang¹, Wei Shi¹, Dan Jian³, Ji Li⁴

Affiliations

¹ Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
² Department of Dermatology, Hunan Loudi Hospital, Loudi, China.
³ Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China. Electronic address: [email protected].
⁴ Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China; Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: [email protected].

PMID: 25818871
DOI: 10.1016/j.jdermsci.2015.02.019

No abstract available

Keywords: ADMA; MMP-1; ROS; Skin senescence; miR-138; p38MAPK.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Acetylcysteine / pharmacology
Arginine / analogs & derivatives*
Arginine / metabolism
Arginine / pharmacology
Back
Cells, Cultured
Cellular Senescence / drug effects*
Child
Enzyme Inhibitors / pharmacology
Face
Fibroblasts / metabolism*
Fibroblasts / radiation effects
Free Radical Scavengers / pharmacology
Humans
Imidazoles / pharmacology
MAP Kinase Signaling System* / drug effects
MicroRNAs / metabolism*
Middle Aged
Pyridines / pharmacology
Reactive Oxygen Species / metabolism
Skin / metabolism*
Skin Aging / physiology
Ultraviolet Rays

Substances

Enzyme Inhibitors
Free Radical Scavengers
Imidazoles
MIRN138 microRNA, human
MicroRNAs
Pyridines
Reactive Oxygen Species
dimethylarginine
Arginine
SB 203580
Acetylcysteine