Space and time: New considerations about the relationship between Toll-like receptors (TLRs) and type I interferons (IFNs)

Darren J Perkins; Stefanie N Vogel

doi:10.1016/j.cyto.2015.03.001

Space and time: New considerations about the relationship between Toll-like receptors (TLRs) and type I interferons (IFNs)

Cytokine. 2015 Aug;74(2):171-4. doi: 10.1016/j.cyto.2015.03.001. Epub 2015 Mar 25.

Authors

Darren J Perkins¹, Stefanie N Vogel²

Affiliations

¹ Department of Microbiology and Immunology, University of Maryland, Baltimore (UMB), School of Medicine, Baltimore, MD 21201, United States.
² Department of Microbiology and Immunology, University of Maryland, Baltimore (UMB), School of Medicine, Baltimore, MD 21201, United States. Electronic address: [email protected].

Abstract

The Toll like receptors (TLRs) and the type I interferons have critical roles to play in innate immunity. In this review we will discuss new developments relating to the important area of TLR/IFN cross regulation.

Keywords: IFN-β; Interferon; LPS; TLR; TRAF3.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Humans
Immunity, Innate*
Interferon Type I / immunology*
Toll-Like Receptors / immunology*

Substances

Interferon Type I
Toll-Like Receptors

Abstract

Publication types

MeSH terms

Substances

Grants and funding