Cervical total disc replacement is superior to anterior cervical decompression and fusion: a meta-analysis of prospective randomized controlled trials

PLoS One. 2015 Mar 30;10(3):e0117826. doi: 10.1371/journal.pone.0117826. eCollection 2015.

Abstract

Background: Despite being considered the standard surgical procedure for symptomatic cervical disc disease, anterior cervical decompression and fusion invariably accelerates adjacent segment degeneration. Cervical total disc replacement is a motion-preserving procedure developed as a substitute to fusion. Whether cervical total disc replacement is superior to fusion remains unclear.

Methods: We comprehensively searched PubMed, EMBASE, Medline, and the Cochrane Library in accordance with the inclusion criteria to identify possible studies. The retrieved results were last updated on December 12, 2014. We classified the studies as short-term and midterm follow-up.

Results: Nineteen randomized controlled trials involving 4516 cases were identified. Compared with anterior cervical decompression and fusion, cervical total disc replacement had better functional outcomes (neck disability index [NDI], NDI success, neurological success, neck pain scores reported on a numerical rating scale [NRS], visual analog scales scores and overall success), greater segmental motion at the index level, fewer adverse events and fewer secondary surgical procedures at the index and adjacent levels in short-term follow-up (P < 0.05). With midterm follow-up, the cervical total disc replacement group indicated superiority in the NDI, neurological success, pain assessment (NRS), and secondary surgical procedures at the index level (P < 0.05). The Short Form 36 (SF-36) and segmental motion at the adjacent level in the short-term follow-up showed no significant difference between the two procedures, as did the secondary surgical procedure rates at the adjacent level with midterm follow-up (P > 0.05).

Conclusions: Cervical total disc replacement presented favorable functional outcomes, fewer adverse events, and fewer secondary surgical procedures. The efficacy and safety of cervical total disc replacement are superior to those of fusion. Longer-term, multicenter studies are required for a better evaluation of the long-term efficacy and safety of the two procedures.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cervical Vertebrae / surgery*
  • Decompression, Surgical* / adverse effects
  • Decompression, Surgical* / methods
  • Humans
  • Intervertebral Disc Degeneration / diagnosis
  • Intervertebral Disc Degeneration / surgery*
  • Intervertebral Disc Displacement / diagnosis
  • Intervertebral Disc Displacement / surgery*
  • Neck Pain / etiology
  • Odds Ratio
  • Pain Measurement
  • Prospective Studies
  • Randomized Controlled Trials as Topic
  • Range of Motion, Articular
  • Retreatment
  • Spinal Fusion* / adverse effects
  • Spinal Fusion* / methods
  • Total Disc Replacement* / adverse effects
  • Total Disc Replacement* / methods
  • Treatment Outcome

Supplementary concepts

  • Intervertebral disc disease

Grants and funding

This study was partly supported by a grant from the National Nature Science Foundation of China (81401822 and 81171756), and the key Science and Technology Planning Project (2012C13G2010083) and (2012C33121) and Nature Science Foundation (Q14H060007 and Y13H060001) of ZhejiangProvince (http://www.nsfc.gov.cn/, http://www.zjnsf.gov.cn/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.