Abstract
BK virus (BKV) is associated with kidney and bladder disease after hematopoietic cell transplantation (HCT) but less is known about the seroprevalence of pre-transplant antibodies to BKV in children. We measured BKV IgG antibody titers in 36 children before HCT. BKV IgG antibodies were detected in all 36 patients, with 28/36 (77.8%) developing BK viremia in the first 100 days. Pre-HCT BKV IgG antibody titers >1:40,960 were protective against later BK viremia ≥10,000 copies/ml. The seroprevalence of antibodies to BKV is high in children undergoing HCT and post-transplant BK viremia, which is associated with bladder and kidney injury, is common.
Keywords:
BK virus; hematopoietic cell transplant; humoral immunity; pediatrics.
© 2015 Wiley Periodicals, Inc.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Antibodies, Viral / blood*
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BK Virus / immunology*
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BK Virus / isolation & purification
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BK Virus / physiology
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Child
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Cystitis / etiology
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Cystitis / virology
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Disease Susceptibility
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Female
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Hematopoietic Stem Cell Transplantation* / adverse effects
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Hematuria / etiology
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Hematuria / virology
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Humans
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Male
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Polyomavirus Infections / blood
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Polyomavirus Infections / epidemiology
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Polyomavirus Infections / immunology*
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Risk
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Seroepidemiologic Studies
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Transplantation Conditioning / adverse effects
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Tumor Virus Infections / blood
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Tumor Virus Infections / epidemiology
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Tumor Virus Infections / immunology*
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Viral Load
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Viremia / epidemiology
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Viremia / etiology
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Virus Activation*