Abstract
In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug resistance in the RT region.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Child
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Evolution, Molecular*
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Female
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Genetic Variation*
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Genotype
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HIV Reverse Transcriptase / genetics*
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HIV-1 / classification
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HIV-1 / enzymology*
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HIV-1 / genetics
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HIV-1 / immunology*
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Humans
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Male
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Middle Aged
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Molecular Sequence Data
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Selection, Genetic
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Sequence Analysis, DNA
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T-Lymphocytes, Cytotoxic / immunology*
Substances
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reverse transcriptase, Human immunodeficiency virus 1
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HIV Reverse Transcriptase