Planar Mn4O cluster homochiral metal-organic framework for HPLC separation of pharmaceutically important (±)-ibuprofen racemate

Inorg Chem. 2015 Apr 20;54(8):3713-5. doi: 10.1021/ic502861k. Epub 2015 Apr 7.

Abstract

A planar tetracoordinated oxygen containing a homochiral metal-organic framework (MOF) has been synthesized and characterized that can be used as a new chiral stationary phase in high-performance liquid chromatography to efficiently separate racemates such as pharmaceutically important (±)-ibuprofen and (±)-1-phenyl-1,2-ethanediol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, High Pressure Liquid
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry*
  • Ethylene Glycols / chemistry
  • Ethylene Glycols / isolation & purification
  • Ibuprofen / chemistry*
  • Ibuprofen / isolation & purification*
  • Manganese Compounds / chemistry*
  • Oxides / chemistry*
  • Quantum Theory
  • Stereoisomerism

Substances

  • Coordination Complexes
  • Ethylene Glycols
  • Manganese Compounds
  • Oxides
  • styrene glycol
  • Ibuprofen