Neurofibromatosis type 1-associated hypertension secondary to coarctation of the thoracic aorta

Clin Kidney J. 2014 Aug;7(4):394-5. doi: 10.1093/ckj/sfu054. Epub 2014 Jun 5.

Abstract

Neurofibromatosis type 1 (NF-1), also known as von Recklinghausen's disease, is an autosomal dominant genetic disorder. NF-I vasculopathy has been used to describe various vascular malformations associated with NF-1. Secondary hypertension related to NF-1 vasculopathy has been reported because of renal artery stenosis, coarctation of the abdominal aorta and other vascular lesions; however, coarctation of the thoracic aorta has seldom been reported. We report the first case, to our knowledge, of isolated coarctation of thoracic aorta in a pregnant female with NF-1. Healthcare providers caring for patients with NF-1 should be aware of associated vascular complications.

Keywords: NF-1; aorta; coarctation; vasculopathy.