Bleomycin-induced flagellate erythema in a patient with Hodgkin's lymphoma - A case report and review of literature

J Oncol Pharm Pract. 2016 Jun;22(3):556-60. doi: 10.1177/1078155215580468. Epub 2015 Apr 8.

Abstract

Bleomycin is a glycopeptide used as a chemotherapeutic agent for lymphomas, germ cell tumors, and pleurodesis of malignant pleural effusions. The pulmonary toxicity of bleomycin is well known while the cutaneous side effects are uncommon and varies from generalized hyperpigmentation, sclerodermoid changes, erythema multiformae, and gangrene to flagellate dermatosis. Here we report a characteristic but rare side effect of flagellate erythema, which developed secondary to bleomycin in a 27-year old woman with Hodgkin's lymphoma after two cycles of treatment with adriamycin, bleomycin, vinblastine, dacarbazine regimen. The rash subsided after discontinuation of bleomycin and treatment with steroids.

Keywords: Bleomycin; Hodgkin’s lymphoma; flagellate erythema; steroids.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antibiotics, Antineoplastic / adverse effects*
  • Bleomycin / adverse effects*
  • Erythema / chemically induced*
  • Erythema / diagnostic imaging
  • Female
  • Hodgkin Disease / diagnostic imaging
  • Hodgkin Disease / drug therapy*
  • Humans

Substances

  • Antibiotics, Antineoplastic
  • Bleomycin