Cell-based screening: extracting meaning from complex data

Steven Finkbeiner; Michael Frumkin; Paul D Kassner

doi:10.1016/j.neuron.2015.02.023

Cell-based screening: extracting meaning from complex data

Neuron. 2015 Apr 8;86(1):160-74. doi: 10.1016/j.neuron.2015.02.023.

Authors

Steven Finkbeiner¹, Michael Frumkin², Paul D Kassner³

Affiliations

¹ Director of the Taube/Koret Center for Neurodegenerative Disease and the Hellman Family Foundation Program in Alzheimer's Disease Research, Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: [email protected].
² Director of Engineering, Research, Google, Inc., 1600 Amphitheatre Parkway, Mountain View, CA 94043, USA.
³ Director of Research, Amgen, Inc., 1120 Veterans Boulevard South, San Francisco, CA 94080, USA.

Abstract

Unbiased discovery approaches have the potential to uncover neurobiological insights into CNS disease and lead to the development of therapies. Here, we review lessons learned from imaging-based screening approaches and recent advances in these areas, including powerful new computational tools to synthesize complex data into more useful knowledge that can reliably guide future research and development.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Central Nervous System Diseases / therapy
Computer Simulation
Databases, Factual*
Humans
Induced Pluripotent Stem Cells / physiology*
Research*

Abstract

Publication types

MeSH terms

Grants and funding