Host autophagy combating S. aureus: α-toxin will be tolerated

Michael E Powers; Juliane Bubeck Wardenburg

doi:10.1016/j.chom.2015.03.010

Host autophagy combating S. aureus: α-toxin will be tolerated

Cell Host Microbe. 2015 Apr 8;17(4):419-20. doi: 10.1016/j.chom.2015.03.010.

Authors

Michael E Powers¹, Juliane Bubeck Wardenburg²

Affiliations

¹ Department of Microbiology, University of Chicago, Chicago, IL 60637, USA.
² Department of Microbiology, University of Chicago, Chicago, IL 60637, USA; Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA. Electronic address: [email protected].

Abstract

Autophagy regulates the degradation of both cellular components and invading intracellular pathogens. In this issue of Cell Host & Microbe, Maurer et al. (2015) reveal that cellular autophagy decreases host sensitivity to Staphylococcus aureus α-toxin via reduced expression of the toxin receptor ADAM10, thus rendering the host tolerant to disease.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Autophagy*
Bacterial Toxins / immunology*
Hemolysin Proteins / immunology*
Immune Tolerance*
Methicillin-Resistant Staphylococcus aureus / immunology*

Substances

Bacterial Toxins
Hemolysin Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding