Abstract
A novel thermo-sensitive micelle contrast agent and its enhancement of MRI contrast with temperature are reported. The morphology changes sharply near 37 °C, resulting in a significant amplification of the CEST signal. This enables detection of small changes in body temperature.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylamides / chemistry
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Body Temperature
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Contrast Media / chemistry
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Coordination Complexes / chemistry
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Europium / chemistry
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Heterocyclic Compounds, 1-Ring / chemistry
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Magnetic Resonance Imaging / methods*
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Methacrylates / chemistry
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Micelles*
Substances
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Acrylamides
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Contrast Media
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Coordination Complexes
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Heterocyclic Compounds, 1-Ring
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Methacrylates
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Micelles
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poly(N-isopropylacrylamide-b-methyl methacrylate)
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1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
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Europium