Common side reactions of the glycosyl donor in chemical glycosylation

Carbohydr Res. 2015 May 18:408:51-95. doi: 10.1016/j.carres.2015.02.007. Epub 2015 Feb 25.

Abstract

Chemical glycosylation is central to carbohydrate chemistry and is generally recognised as a challenging reaction. This review describes the most reoccurring side reactions of glycosyl donors in glycosylation and how scientists have attempted to explain their observations and in some cases succeeded in solving a particular encountered problem. The topics covered are donor hydrolysis, elimination to form glycals, intermolecular aglycon transfer of thioglycosides and glycosyl imidate rearrangement.

Keywords: By-products; Elimination; Hydrolysis; Thioglycosides; Trichloroacetimidates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Glycosylation
  • Hydrolysis
  • Molecular Structure
  • Thioglycosides / chemistry*

Substances

  • Thioglycosides