Simvastatin improves hematopoietic stem cell engraftment by preventing irradiation-induced marrow adipogenesis and radio-protecting the niche cells

Haematologica. 2015 Aug;100(8):e323-7. doi: 10.3324/haematol.2015.124750. Epub 2015 Apr 17.
No abstract available

Keywords: HSC engraftment; HSC-Niche; marrow adipogenesis; radioprotection; simvastatin.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipogenesis / drug effects*
  • Adipogenesis / radiation effects
  • Animals
  • Bone Marrow / drug effects
  • Bone Marrow / pathology
  • Bone Marrow / radiation effects
  • Graft Survival / drug effects*
  • Graft Survival / radiation effects
  • Hematopoietic Stem Cell Transplantation
  • Hematopoietic Stem Cells / drug effects*
  • Hematopoietic Stem Cells / radiation effects
  • Mice
  • Radiation-Protective Agents / pharmacology*
  • Simvastatin / pharmacology*
  • Stem Cell Niche / drug effects*
  • Stem Cell Niche / radiation effects
  • Transplantation Conditioning / adverse effects
  • Transplantation Conditioning / methods

Substances

  • Radiation-Protective Agents
  • Simvastatin