Involvement of BAG3 and HSPB7 loci in various etiologies of systolic heart failure: Results of a European collaboration assembling more than 2000 patients

Sophie Garnier; Christian Hengstenberg; Nicolas Lamblin; Olivier Dubourg; Pascal De Groote; Laurent Fauchier; Jean-Noël Trochu; Eloisa Arbustini; Ulrike Esslinger; Paul J Barton; Benjamin Meder; Hugo Katus; Karen Frese; Michel Komajda; Stuart A Cook; Richard Isnard; Laurence Tiret; Eric Villard; Philippe Charron

doi:10.1016/j.ijcard.2015.04.003

Involvement of BAG3 and HSPB7 loci in various etiologies of systolic heart failure: Results of a European collaboration assembling more than 2000 patients

Int J Cardiol. 2015:189:105-7. doi: 10.1016/j.ijcard.2015.04.003. Epub 2015 Apr 1.

Authors

Sophie Garnier¹, Christian Hengstenberg², Nicolas Lamblin³, Olivier Dubourg⁴, Pascal De Groote³, Laurent Fauchier⁵, Jean-Noël Trochu⁶, Eloisa Arbustini⁷, Ulrike Esslinger⁸, Paul J Barton⁹, Benjamin Meder¹⁰, Hugo Katus¹⁰, Karen Frese¹⁰, Michel Komajda¹¹, Stuart A Cook¹², Richard Isnard¹³, Laurence Tiret¹⁴, Eric Villard¹⁵, Philippe Charron¹⁶

Affiliations

¹ INSERM, UMR_S 1166, F-75013 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, F-75013 Paris, France; ICAN Institute for Cardiometabolism and Nutrition, F-75013 Paris, France. Electronic address: [email protected].
² University of Regensburg, Department of Internal Medicine II, Regensburg, Germany.
³ Hôpital Régional Universitaire de Lille, Hôpital Cardiologique, Lille, France.
⁴ Hôpital Ambroise Paré AP-HP, Paris, France; Université de Versailles Saint Quentin en Yvelines, Versailles, France.
⁵ Hôpital Régional Universitaire de Tours, Tours, France.
⁶ INSERM UMR 1087, Nantes, France.
⁷ IRCCS Foundation Policlinico San Matteo, Center for Genetic Cardiovascular Diseases, Pavia, Italy.
⁸ INSERM, UMR_S 1166, F-75013 Paris, France; ICAN Institute for Cardiometabolism and Nutrition, F-75013 Paris, France; University of Regensburg, Department of Internal Medicine II, Regensburg, Germany.
⁹ Royal Brompton & Harefield NHS Foundation Trust's NIHR Cardiovascular Biomedical Research Unit, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
¹⁰ University Hospital Heidelberg, Heidelberg, Germany.
¹¹ INSERM, UMR_S 1166, F-75013 Paris, France; ICAN Institute for Cardiometabolism and Nutrition, F-75013 Paris, France; Université Paris 6 & AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France.
¹² National Heart and Lung Institute, Imperial College London, London, United Kingdom; National Heart Centre Singapore, Singapore; Duke-NUS, Singapore.
¹³ INSERM, UMR_S 1166, F-75013 Paris, France; Université Paris 6 & AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France.
¹⁴ INSERM, UMR_S 1166, F-75013 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, F-75013 Paris, France; ICAN Institute for Cardiometabolism and Nutrition, F-75013 Paris, France.
¹⁵ INSERM, UMR_S 1166, F-75013 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, F-75013 Paris, France; ICAN Institute for Cardiometabolism and Nutrition, F-75013 Paris, France; Université Paris 6 & AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France.
¹⁶ INSERM, UMR_S 1166, F-75013 Paris, France; ICAN Institute for Cardiometabolism and Nutrition, F-75013 Paris, France; Hôpital Ambroise Paré AP-HP, Paris, France; Université de Versailles Saint Quentin en Yvelines, Versailles, France.

PMID: 25889438
DOI: 10.1016/j.ijcard.2015.04.003

No abstract available

Keywords: Association studies; Dilated cardiomyopathy; Genetics; Ischemic heart failure.

Publication types

Comparative Study
Letter
Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing / genetics*
Age Distribution
Aged
Aged, 80 and over
Apoptosis Regulatory Proteins / genetics*
Cardiomyopathy, Dilated / etiology
Cardiomyopathy, Dilated / genetics*
Cardiomyopathy, Dilated / mortality
Cardiomyopathy, Dilated / therapy
Case-Control Studies
Cohort Studies
Europe
Female
France
Gene Expression Regulation*
Genetic Loci
Genome-Wide Association Study
Genotype
Germany
HSP27 Heat-Shock Proteins / genetics*
Heart Failure, Systolic / etiology
Heart Failure, Systolic / genetics*
Heart Failure, Systolic / mortality
Heart Failure, Systolic / therapy
Humans
Incidence
Internationality
Italy
Male
Middle Aged
Prognosis
Risk Assessment
Sex Distribution
Survival Analysis

Substances

Adaptor Proteins, Signal Transducing
Apoptosis Regulatory Proteins
BAG3 protein, human
HSP27 Heat-Shock Proteins
HSPB7 protein, human

Publication types

MeSH terms

Substances

Grants and funding