Upper gastrointestinal bleeding - state of the art

Folia Med Cracov. 2014;54(4):59-78.

Abstract

Upper gastrointestinal (GI) bleeding is a condition requiring immediate medical intervention, with high associated mortality exceeding 10%. The most common cause of upper GI bleeding is peptic ulcer disease, which largely corresponds to the intake of NSAIDs and Helicobacter pylori infection. Endoscopy is the essential tool for the diagnosis and treatment of active upper GI hemorrhage. Endoscopic therapy together with proton pump inhibitors and eradication of Helicobacter pylori significantly reduces rebleeding rates, mortality and number of emergency surgical interventions. This paper presents contemporary data on the diagnosis and treatment of upper gastrointestinal bleeding.

Keywords: endoscopy; upper GI bleeding.

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Cyclooxygenase Inhibitors / adverse effects
  • Esophagitis / complications
  • Gastrointestinal Hemorrhage / diagnosis*
  • Gastrointestinal Hemorrhage / etiology
  • Gastrointestinal Hemorrhage / prevention & control
  • Gastrointestinal Hemorrhage / therapy*
  • Helicobacter Infections / complications
  • Humans
  • Peptic Ulcer Hemorrhage / diagnosis
  • Peptic Ulcer Hemorrhage / therapy
  • Prognosis
  • Recurrence
  • Risk Factors

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Cyclooxygenase Inhibitors