Assessment of seizure risk in pre-clinical studies: Strengths and limitations of the electroencephalogram (EEG)

Monica Metea; Mona Litwak; Joseph Arezzo

doi:10.1016/j.vascn.2015.04.001

Assessment of seizure risk in pre-clinical studies: Strengths and limitations of the electroencephalogram (EEG)

J Pharmacol Toxicol Methods. 2015 Sep-Oct:75:135-42. doi: 10.1016/j.vascn.2015.04.001. Epub 2015 Apr 16.

Authors

Monica Metea¹, Mona Litwak², Joseph Arezzo³

Affiliations

¹ Smithers Viscient Laboratories, United States. Electronic address: [email protected].
² Department of Neuroscience, Albert Einstein College of Medicine, United States.
³ Department of Neuroscience, Albert Einstein College of Medicine, United States; Department of Neurology, Albert Einstein College of Medicine, United States.

PMID: 25891491
DOI: 10.1016/j.vascn.2015.04.001

No abstract available

Keywords: Convulsions; EEG spectral analysis; Electromyography/EMG; Preclinical seizure risk assessment; Premonitory signs; Regulatory drug development; Safety pharmacology; Seizure; Sharp waves; Telemetry; Tremors; Video-EEG.

MeSH terms

Animals
Drug Evaluation, Preclinical / methods*
Drug-Related Side Effects and Adverse Reactions / diagnosis
Drug-Related Side Effects and Adverse Reactions / physiopathology
Electroencephalography / methods*
Humans
Seizures / chemically induced*
Seizures / diagnosis
Telemetry / methods