Abstract
A new dammarane-type triterpenoid compound was isolated from stems and leaves of American ginseng. The structure of the new sapogenin was elucidated by the combined analysis of NMR and HR-ESI-MS as dammar-20S, 25S-epoxy-3β, 12β, 26-triol (1). Compound 1 showed cytotoxic effect on human SM7721 and human Hela cells in vitro.
Keywords:
12β; 25S-epoxy-3β; 26-triol; cytotoxic effect; dammar-20S; dammarane-type triterpene; stems and leaves of American ginseng.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Dammaranes
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Drug Screening Assays, Antitumor
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HeLa Cells / drug effects
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Humans
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Panax / chemistry*
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Plant Leaves / chemistry*
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Plant Stems / chemistry*
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Triterpenes / chemistry*
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Triterpenes
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dammar-20S, 25S-epoxy-3beta, 12beta, 26-triol