[Complete genome characterization of the Kyzylagach virus (KYZV) (Togaviridae, Alphavirus, Sindbis serogroup) isolated from mosquitoes Culex modestus Ficalbi, 1889 (Culicinae) collected in a colony of herons (Ardeidae Leach, 1820) in Azerbaijan]

Vopr Virusol. 2014;59(5):27-31.
[Article in Russian]

Abstract

Complete genome sequencing of the Kyzylagach virus (KYZV) LEIV-65A strain isolated from the Culex modestus Ficalbi, 1889 (Culicinae), which was collected in the colony of the Ardeidae Leach, 1820 birds on the coast of Caspian sea, Kyzyl-Agach bay, in the southern part of Azerbaijan, was carried out. KYZV has high homology (about 99%) with the Chinese XJ-160 strain of the Sindbis virus (SINV) isolated from Anopheles sp. in Xinjiang Uyghur autonomic region (north-eastern China). Homologies of KYZV and XJ-160 with European SINV strains are 82% and 93% for the nucleotide and amino acid sequences, respectively (GenBank ID: KF981618). The difference between the nucleotide sequences of KYZV and Australian SINV/SW6562 strain is 19%; amino acid sequences, 12%. Since XJ-160 strain is extremely similar to KYZV, the first could be considered as the KYZV strain. The geography of the KYZV and XJ-160 isolation points and their genetic distance from the European viruses allow the KYZV to be suggested as a SINV (genotype IV) topotypic variant typical of Transcaucasia and Central Asia.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alphavirus Infections / epidemiology
  • Alphavirus Infections / transmission
  • Alphavirus Infections / veterinary*
  • Alphavirus Infections / virology
  • Amino Acid Sequence
  • Animals
  • Azerbaijan / epidemiology
  • Base Sequence
  • Birds / virology*
  • Culex / virology*
  • Disease Vectors
  • Genome, Viral*
  • High-Throughput Nucleotide Sequencing
  • Molecular Sequence Data
  • Phylogeny*
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
  • Sindbis Virus / classification
  • Sindbis Virus / genetics*
  • Sindbis Virus / isolation & purification
  • Viral Proteins / genetics*

Substances

  • Viral Proteins

Associated data

  • GENBANK/KF981618