A platinum prodrug conjugated with a photosensitizer with aggregation-induced emission (AIE) characteristics for drug activation monitoring and combinatorial photodynamic-chemotherapy against cisplatin resistant cancer cells

Youyong Yuan; Chong-Jing Zhang; Bin Liu

doi:10.1039/c5cc01952d

A platinum prodrug conjugated with a photosensitizer with aggregation-induced emission (AIE) characteristics for drug activation monitoring and combinatorial photodynamic-chemotherapy against cisplatin resistant cancer cells

Chem Commun (Camb). 2015 May 21;51(41):8626-9. doi: 10.1039/c5cc01952d.

Authors

Youyong Yuan¹, Chong-Jing Zhang, Bin Liu

Affiliation

¹ Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore117585. [email protected].

PMID: 25898264
DOI: 10.1039/c5cc01952d

Abstract

A targeted and image-guided platinum prodrug conjugated with a photosensitizer with aggregation-induced emission (AIE) characteristics was designed for real-time and in situ drug activation monitoring in cancer cells as well as combinational photodynamic-chemotherapy against cisplatin resistant cancer cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / chemistry
Antineoplastic Combined Chemotherapy Protocols / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Survival / drug effects
Cisplatin / chemistry
Cisplatin / pharmacology*
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm / drug effects*
Drug Screening Assays, Antitumor
HEK293 Cells
Humans
MCF-7 Cells
Molecular Structure
Organoplatinum Compounds / chemistry
Organoplatinum Compounds / pharmacology*
Photochemotherapy*
Photosensitizing Agents / chemistry
Photosensitizing Agents / pharmacology*
Prodrugs / chemistry
Prodrugs / pharmacology*
Structure-Activity Relationship

Substances

Organoplatinum Compounds
Photosensitizing Agents
Prodrugs
Cisplatin