Antiretroviral therapy-induced toxicity is associated with increased mRNA expression of telomerase

J Clin Pharmacol. 2015 Oct;55(10):1119-24. doi: 10.1002/jcph.520. Epub 2015 May 28.

Authors

Min Li¹, Yram Foli¹, Nana Y Amakye², Taline Klein³, Shanmugapriya Selvaraj¹, Lingeng Lu⁴, Elijah Paintsil^{1

4

5}

Affiliations

¹ Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
² Department of Cell Physiology and Pharmacology, School of Biological Sciences, University of Leicester, Leicester, UK.
³ Department of Internal Medicine, University of São Paulo Medical School at Ribeirão Preto, São Paulo, Brazil.
⁴ Department of Epidemiology & Public Health, Yale School of Medicine, New Haven, CT, USA.
⁵ Department of Pharmacology, New Haven, CT, USA.

No abstract available

Keywords: antiretroviral therapy; immune activation; mitochondrial toxicity; telomerase; telomere length.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Aged
Case-Control Studies
Female
HIV Infections / drug therapy
HIV Infections / enzymology*
HIV Infections / epidemiology
Humans
Male
Middle Aged
RNA, Messenger / metabolism
Reverse Transcriptase Inhibitors / therapeutic use
Telomerase / genetics*

Substances

RNA, Messenger
Reverse Transcriptase Inhibitors
TERT protein, human
Telomerase

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