Regioselective Synthesis of Multisubstituted Furans via Copper-Mediated Coupling between Ketones and β-Nitrostyrenes

J Org Chem. 2015 May 15;80(10):5364-8. doi: 10.1021/acs.joc.5b00704. Epub 2015 Apr 30.

Abstract

A copper-mediated intermolecular annulation of alkyl ketones and β-nitrostyrenes has been developed for the regioselective synthesis of multisubstituted furan derivatives in good yields. This protocol is applicable to both cyclic and acyclic ketones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Copper / chemistry*
  • Furans / chemical synthesis*
  • Furans / chemistry
  • Ketones / chemistry*
  • Molecular Structure
  • Stereoisomerism
  • Styrenes / chemistry*

Substances

  • Furans
  • Ketones
  • Styrenes
  • beta-nitrostyrene
  • Copper