The aging prostate is never "normal": implications from the genomic characterization of multifocal prostate cancers

Eur Urol. 2015 Sep;68(3):348-50. doi: 10.1016/j.eururo.2015.04.012. Epub 2015 Apr 22.

Abstract

We argue against the recently published statement that tumor-specific molecular alterations found in "normal" prostate tissue from cancer patients challenge focal therapy approaches that only target a visible cancer lesion and not the adjacent molecular field.

Publication types

  • Editorial

MeSH terms

  • Aging / genetics*
  • Aging / metabolism
  • Genetic Heterogeneity
  • Genomics
  • Humans
  • Male
  • Neoplasms, Multiple Primary / genetics*
  • Neoplasms, Multiple Primary / metabolism
  • Oncogene Proteins, Fusion / metabolism
  • Prostate / metabolism*
  • Prostatic Neoplasms / genetics*
  • Prostatic Neoplasms / metabolism

Substances

  • Oncogene Proteins, Fusion
  • TMPRSS2-ERG fusion protein, human