Successful treatment of immediate allogeneic myeloablative hematopoietic stem cell transplantation from a HLA-mismatched sibling donor for active systemic epstein-barr virus-positive T-cell lymphoproliferative disease of childhood following primary acute epstein-barr virus infection

Yasutaka Kakinoki; Satomi Matsuoka; Junichi Hashiguchi; Koji Chiba; Takayoshi Miyake

doi:10.1002/ccr3.204

Successful treatment of immediate allogeneic myeloablative hematopoietic stem cell transplantation from a HLA-mismatched sibling donor for active systemic epstein-barr virus-positive T-cell lymphoproliferative disease of childhood following primary acute epstein-barr virus infection

Clin Case Rep. 2015 Apr;3(4):231-6. doi: 10.1002/ccr3.204. Epub 2015 Feb 2.

Authors

Yasutaka Kakinoki¹, Satomi Matsuoka², Junichi Hashiguchi¹, Koji Chiba¹, Takayoshi Miyake¹

Affiliations

¹ Department of Hematology, Asahikawa City Hospital Asahikawa, Japan.
² Department of Hematology, Hokkaido University Graduate School of Medicine Sapporo, Japan.

Abstract

A 22-year-old female was admitted for sustained high fever and diagnosed with systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease. As her clinical course was so aggressive, she immediately underwent allogeneic myeloablative bone marrow transplantation from an HLA-mismatched sibling donor on hospital day 46. The patient has remained in complete remission for 3 years.

Keywords: EBV-positive T-cell LPD; HPS; HSCT; MAC.

Publication types

Case Reports