Effect of adenosine on fructose 2,6-bisphosphate levels and glucose metabolization by chicken erythrocytes

C Espinet; R Bartrons; J Carreras

doi:10.1016/0014-5793(89)81635-7

Effect of adenosine on fructose 2,6-bisphosphate levels and glucose metabolization by chicken erythrocytes

FEBS Lett. 1989 Nov 20;258(1):143-6. doi: 10.1016/0014-5793(89)81635-7.

Authors

C Espinet¹, R Bartrons, J Carreras

Affiliation

¹ Department of Ciéncies Fisiològiques, Humanes i de la Nutrició, Facultat de Medicina, Univesitat de Barcelona, Spain.

PMID: 2591530
DOI: 10.1016/0014-5793(89)81635-7

Abstract

Adenosine can be metabolized by chicken erythrocytes as a carbon source maintaining ATP levels. In addition, it stimulates glucose uptake and lactate production. Adenosine effects do not involve binding to membrane receptors. They are dependent on the provision of a carbon source to glycolysis and correlate with the increase of fructose 2,6-bisphosphate levels that activating phosphofructokinase would increase the glycolytic flux.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine / metabolism
Adenosine / pharmacology*
Adenosine Triphosphate / metabolism
Animals
Chickens
Erythrocytes / metabolism*
Fructosediphosphates / metabolism*
Glucose / metabolism*
Glycolysis / drug effects
Hexosediphosphates / metabolism*
Lactates / metabolism

Substances

Fructosediphosphates
Hexosediphosphates
Lactates
fructose 2,6-diphosphate
Adenosine Triphosphate
Glucose
Adenosine