First description of azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation in France

Rose-Anne Lavergne; Florent Morio; Loïc Favennec; Stéphane Dominique; Jacques F Meis; Gilles Gargala; Paul E Verweij; Patrice Le Pape

doi:10.1128/AAC.00127-15

First description of azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation in France

Antimicrob Agents Chemother. 2015 Jul;59(7):4331-5. doi: 10.1128/AAC.00127-15. Epub 2015 Apr 27.

Authors

Rose-Anne Lavergne¹, Florent Morio¹, Loïc Favennec², Stéphane Dominique³, Jacques F Meis⁴, Gilles Gargala², Paul E Verweij⁵, Patrice Le Pape⁶

Affiliations

¹ Département de Parasitologie et Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155-IICiMed, Faculté de Pharmacie, Nantes, France Laboratoire de Parasitologie-Mycologie, Institut de Biologie, CHU de Nantes, Nantes, France.
² EA3800, Laboratoire de Parasitologie-Mycologie, Université de Rouen et CHU de Rouen, Rouen, France.
³ Department of Pneumology, Cystic Fibrosis Center, Rouen University Hospital, Rouen, France.
⁴ Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
⁵ Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
⁶ Département de Parasitologie et Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155-IICiMed, Faculté de Pharmacie, Nantes, France Laboratoire de Parasitologie-Mycologie, Institut de Biologie, CHU de Nantes, Nantes, France [email protected].

Abstract

Azole resistance in Aspergillus fumigatus is an emerging public health concern. Recently, a novel fungicide-driven mutation in the cyp51A gene and its promoter, TR46/Y121F/T289A, leading to high-level resistance to voriconazole has been identified in The Netherlands, Belgium, Germany, Denmark, Tanzania, and India in both clinical and environmental samples. Here we report the first description of A. fumigatus carrying this mutation in France, in a cystic fibrosis patient, underlining the need for extensive monitoring of Aspergillus resistance.

Publication types

Case Reports

MeSH terms

Anti-Bacterial Agents / pharmacology*
Antibodies, Fungal / analysis
Aspergillosis / microbiology
Aspergillus fumigatus / drug effects*
Aspergillus fumigatus / genetics*
Azoles / pharmacology*
Cystic Fibrosis / microbiology
Cytochrome P-450 Enzyme System / genetics*
Drug Resistance, Fungal / genetics*
Europe
France
Fungal Proteins / genetics*
Humans
Immunoglobulin E / analysis
Itraconazole / pharmacology
Male
Mutation / genetics
Retrospective Studies
Voriconazole / pharmacology
Young Adult

Substances

Anti-Bacterial Agents
Antibodies, Fungal
Azoles
Fungal Proteins
Itraconazole
Immunoglobulin E
Cytochrome P-450 Enzyme System
cytochrome P-450 CYP51A, Aspergillus
Voriconazole