A direct access to heptasubstituted biguanides

Mol Divers. 2015 Nov;19(4):703-8. doi: 10.1007/s11030-015-9601-7. Epub 2015 Apr 30.

Abstract

An efficient and experimentally simple copper-catalyzed carbon-nitrogen bond formation for the synthesis of [Formula: see text]-arylated biguanides starting from aryl halides, carbodiimides, and 1,1,3,3-tetramethylguanidine is reported. The potential diversity of this type of reaction, easily available starting materials, and commercially available low-cost catalysts are the incremental features of this methodology.

Keywords: -Arylation; Biguanides; Carbodiimides; Copper-catalyzed; Tetramethylguanidine.

MeSH terms

  • Biguanides / chemical synthesis*
  • Biguanides / chemistry
  • Catalysis
  • Copper / chemistry*
  • Molecular Structure

Substances

  • Biguanides
  • Copper