Abstract
In this study, the culture supernatant of LPS-treated MSCs was collected and served as a conditioned medium (CM). It was found that the LPS-CM promoted the proliferation of tumor cells (SKBR3, MDA-MB-231, A549, 95D and HepG2). In addition, the colony formation ability was also enhanced by LPS-CM incubation. The inflammatory cytokines, IL-6 and IL-8, were demonstrated to be up-regulated in the LPS-CM, which we supposed to function in the tumor-growth promotion in vitro.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Cell Proliferation / drug effects
-
Humans
-
Interleukin-6 / metabolism
-
Interleukin-8 / metabolism
-
Lipopolysaccharides / pharmacology*
-
Mesenchymal Stem Cells / cytology*
-
Mesenchymal Stem Cells / drug effects*
-
Mesenchymal Stem Cells / metabolism
-
NF-kappa B / metabolism
-
Signal Transduction / drug effects
-
Tumor Microenvironment / drug effects*
-
Up-Regulation / drug effects
Substances
-
Interleukin-6
-
Interleukin-8
-
Lipopolysaccharides
-
NF-kappa B