Examination of the brain natriuretic peptide rs198389 single-nucleotide polymorphism on type 2 diabetes mellitus and related phenotypes in an Algerian population

Gene. 2015 Aug 10;567(2):159-63. doi: 10.1016/j.gene.2015.04.073. Epub 2015 Apr 28.

Abstract

Background: In European populations, the NPPB rs198389 single nucleotide polymorphism (SNP) is associated with a reduced risk of type 2 diabetes mellitus (T2DM). We investigated the putative associations between NPPB rs198389, the T2DM risk and quantitative metabolic traits in an Algerian population.

Methods: The association analysis was performed as a T2DM case-control study (with 78 cases and 645 controls) nested into the ISOR population-based study.

Results: The NPPB rs198389 SNP was not associated with T2DM (odds ratio (OR) [95% confidence interval (CI)]=0.73 [0.51-1.04], p=0.08). However, the C allele was associated with lower fasting plasma insulin levels (p=0.05) and a lower homeostatic model assessment insulin resistance index (p=0.05) in non-diabetic individuals.

Conclusion: The NPPB rs198389 SNP might modulate fasting insulin levels in an Algerian population.

Keywords: BNP; ISOR study; Insulin; NPPB gene; Polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Algeria
  • Case-Control Studies
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / genetics*
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Humans
  • Insulin / blood
  • Insulin Resistance / genetics
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain / genetics*
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Risk

Substances

  • Insulin
  • Natriuretic Peptide, Brain