Alarmins released during local antitumor treatments play an essential role in enhancing tumor growth inhibition at treated and non-treated sites via a derivative of CCL3

Shiro Kanegasaki; Tomoko Tsuchiya

doi:10.4161/21624011.2014.958956

Alarmins released during local antitumor treatments play an essential role in enhancing tumor growth inhibition at treated and non-treated sites via a derivative of CCL3

Oncoimmunology. 2014 Dec 15;3(10):e958956. doi: 10.4161/21624011.2014.958956. eCollection 2014 Nov.

Authors

Shiro Kanegasaki¹, Tomoko Tsuchiya¹

Affiliation

¹ YU-ECI Research Center for Medical Science; Yeungnam University ; Gyengsan, Gyeungbuk, Republic of Korea.

Abstract

ECI301 (eMIP), a single amino-acid substituted CCL3 (MIP-1α), enhanced tumor growth inhibition and the abscopal effect (an effect distal to the target) following local antitumor therapy such as radiation, radiofrequency ablation (RFA), or hyperthermia treatment. The recent elucidation of the underlying mechanism may lead to a better antitumor therapy.

Keywords: CT, computed tomography; ECI301; HMGB1; HMGB1, high mobility group box-1 protein; HSP, heat shock protein; HSP70; MIP-1α; MIP-1α, macrophage inflammatory protein 1α; RFA, radiofrequency ablation; abscopal effect; alarmin; eMIP; hyperthermia; radiation; radiofrequency ablation.