Radioimmunotherapy aims to deliver radiation directly to cancer cells by means of a tumor specific vector coupled to a radionuclide. Alpha radionuclides are very potent agents to treat disseminated cancer and metastasis. We have demonstrated that α radiation can also induce immunogenic cell death, reinforcing interest in their clinical development.
Keywords: 213Bi, bismuth-213; 224Ra, radium-224; DAMPs, danger associated molecular patterns; DC, dendritic cells; HMGB1, high mobility group box 1; Hsp70, 70 kilodalton heat shock protein; RIT; RIT, radioimmunotherapy; abscopal effect; cancer; immunogenic cell death; ionizing radiation; α emitters.