Genome editing technologies: defining a path to clinic
Mol Ther
.
2015 May;23(5):796-806.
doi: 10.1038/mt.2015.54.
Authors
Jacqueline Corrigan-Curay
1
,
Marina O'Reilly
2
,
Donald B Kohn
3
,
Paula M Cannon
4
,
Gang Bao
5
,
Frederic D Bushman
6
,
Dana Carroll
7
,
Toni Cathomen
8
,
J Keith Joung
9
,
David Roth
6
,
Michel Sadelain
10
,
Andrew M Scharenberg
11
,
Christof von Kalle
12
,
Feng Zhang
13
,
Robert Jambou
2
,
Eugene Rosenthal
2
,
Morad Hassani
2
,
Aparna Singh
2
,
Matthew H Porteus
14
Affiliations
1
National Institutes of Health, Bethesda, Maryland, USA. Electronic address:
[email protected]
.
2
National Institutes of Health, Bethesda, Maryland, USA.
3
University of California, Los Angeles, Los Angeles, California, USA.
4
Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
5
Georgia Institute of Technology, Atlanta, Georgia, USA.
6
University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA.
7
University of Utah, School of Medicine, Salt Lake City, Utah, USA.
8
University Medical Center Freiberg, Freiberg, Germany.
9
Massachusetts General Hospital, Charlestown, Massachusetts; Harvard Medical School, Boston, Massachusetts, USA.
10
Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
11
Seattle Children's Research Institute and University of Washington, School of Medicine, Seattle, Washington, USA.
12
National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany.
13
Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.
14
Stanford University, California, Stanford, California, USA.
PMID:
25943494
PMCID:
PMC4427885
DOI:
10.1038/mt.2015.54
No abstract available
Publication types
Congress
MeSH terms
Animals
DNA Breaks, Double-Stranded
DNA Repair
Gene Rearrangement
Genetic Engineering / methods
Genome*
Genomics / methods*
Humans
Models, Animal
Mutagenicity Tests
Translational Research, Biomedical
Grants and funding
R01 AI082020/AI/NIAID NIH HHS/United States
R01 GM078571/GM/NIGMS NIH HHS/United States