Ascosteroside C, a new mitochondrial respiration inhibitor discovered by pesticidal screening using recombinant Saccharomyces cerevisiae

J Antibiot (Tokyo). 2015 Oct;68(10):649-52. doi: 10.1038/ja.2015.43. Epub 2015 May 6.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Antineoplastic Agents
  • Culture Media
  • Drug Evaluation, Preclinical
  • Drug Screening Assays, Antitumor
  • Electron Transport / drug effects
  • Glycosides / pharmacology*
  • HeLa Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mitochondria / drug effects
  • Mitochondria / metabolism*
  • Molecular Conformation
  • Oxygen Consumption / drug effects
  • Pesticides / pharmacology*
  • Saccharomyces cerevisiae / drug effects*
  • Saccharomyces cerevisiae / genetics
  • Triterpenes / pharmacology*

Substances

  • Antineoplastic Agents
  • Culture Media
  • Glycosides
  • Pesticides
  • Triterpenes
  • ascosteroside
  • ascosteroside C
  • Adenosine Triphosphate