Molecular characterization and antimicrobial susceptibilities of Clostridium difficile clinical isolates from Victoria, Australia

Kate E Mackin; Briony Elliott; Despina Kotsanas; Benjamin P Howden; Glen P Carter; Tony M Korman; Thomas V Riley; Julian I Rood; Grant A Jenkin; Dena Lyras

doi:10.1016/j.anaerobe.2015.05.001

Molecular characterization and antimicrobial susceptibilities of Clostridium difficile clinical isolates from Victoria, Australia

Anaerobe. 2015 Aug:34:80-3. doi: 10.1016/j.anaerobe.2015.05.001. Epub 2015 May 2.

Authors

Affiliations

¹ Department of Microbiology, Monash University, Clayton, VIC, Australia.
² School of Pathology and Laboratory Medicine, The University of Western Australia, Nedlands, WA, Australia.
³ Monash Infectious Diseases, Monash Health, Clayton, VIC, Australia.
⁴ Department of Microbiology, Austin Health, Heidelberg, VIC, Australia; Department of Microbiology and Immunology, University of Melbourne, VIC, Australia.
⁵ Monash Infectious Diseases, Monash Health, Clayton, VIC, Australia; Department of Microbiology, Monash Health, Clayton, VIC, Australia.
⁶ School of Pathology and Laboratory Medicine, The University of Western Australia, Nedlands, WA, Australia; PathWest Laboratory Medicine, Nedlands, WA, Australia.
⁷ Department of Microbiology, Monash University, Clayton, VIC, Australia. Electronic address: [email protected].

PMID: 25944720
DOI: 10.1016/j.anaerobe.2015.05.001

Abstract

Some Australian strain types of Clostridium difficile appear unique, highlighting the global diversity of this bacterium. We examined recent and historic local isolates, finding predominantly toxinotype 0 strains, but also toxinotypes V and VIII. All isolates tested were susceptible to vancomycin and metronidazole, while moxifloxacin resistance was only detected in recent strains.

Keywords: Clostridium difficile; Clostridium difficile Australia; Clostridium difficile antibiotic resistance; Clostridium difficile epidemiology; Clostridium difficile toxinotypes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Bacterial Toxins / genetics
Clostridioides difficile / classification
Clostridioides difficile / drug effects
Clostridioides difficile / genetics
Clostridioides difficile / isolation & purification*
Clostridium Infections / microbiology*
Drug Resistance, Bacterial
Fluoroquinolones / pharmacology
Genetic Variation*
Humans
Metronidazole / pharmacology
Microbial Sensitivity Tests
Moxifloxacin
Vancomycin / pharmacology
Victoria

Substances

Anti-Bacterial Agents
Bacterial Toxins
Fluoroquinolones
Metronidazole
Vancomycin
Moxifloxacin