Abstract
Nine new terpenoids (1-3, 5-10), including three cyclolanostane triterpenoids (1-3) and six isopimarane diterpenoids (5-10), along with six known terpenoids (4, 11-15), were isolated from the leaves and twigs of Dysoxylum gotadhora. Compound 1 represents a class of rare natural 21,24-epoxy cyclolanostane-type triterpenoids, and compounds 2 and 3 are the first examples of 21,25-epoxy cyclolanostane-type triterpenoids. Compounds 1, 2, 4, 8, and 15 exhibited noteworthy inhibition of nitric oxide production induced by lipopolysaccharide in RAW 264.7 cells with IC50 values of 25.5, 41.5, 27.4, 14.5, and 45.2 μM, respectively.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Inflammatory Agents / chemistry
-
Anti-Inflammatory Agents / isolation & purification*
-
Anti-Inflammatory Agents / pharmacology*
-
Diterpenes / pharmacology
-
Inhibitory Concentration 50
-
Lipopolysaccharides / pharmacology
-
Macrophages / drug effects
-
Meliaceae / chemistry*
-
Mice
-
Molecular Structure
-
Nitric Oxide / biosynthesis
-
Nuclear Magnetic Resonance, Biomolecular
-
Plant Components, Aerial / chemistry
-
Terpenes / chemistry
-
Terpenes / isolation & purification*
-
Terpenes / pharmacology*
-
Triterpenes / pharmacology
Substances
-
Anti-Inflammatory Agents
-
Diterpenes
-
Lipopolysaccharides
-
Terpenes
-
Triterpenes
-
Nitric Oxide