Cord formation in BACTEC(TM) medium aids rapid identification of Mycobacterium tuberculosis complex

Int J Tuberc Lung Dis. 2015 Jun;19(6):709-10. doi: 10.5588/ijtld.14.0586.

Abstract

Mycobacterium tuberculosis complex (MTC) organisms form serpentine cords in fluid culture medium. Reporting of a presumptive identification of MTC based on cording allows rapid identification of patients with tuberculosis. A total of 612 positive mycobacterial cultures from 316 patients over 3 years (2008-2010) were evaluated for the presence of cord formation. Cording was identified in 426 (69.6%) specimens, while the reference laboratory confirmed M. tuberculosis in 424 specimens (69.3%). Sensitivity of the test in our laboratory was 99.1% (95%CI 97.4-99.7) and specificity was 96.8% (95%CI 92.8-98.7). Presumptive identification of M. tuberculosis by the presence of cording formation is both sensitive and specific.

MeSH terms

  • Bacteriological Techniques*
  • Culture Media*
  • Feasibility Studies
  • Humans
  • Mycobacterium tuberculosis / growth & development
  • Mycobacterium tuberculosis / isolation & purification*
  • Predictive Value of Tests
  • Reproducibility of Results
  • Retrospective Studies
  • Time Factors
  • Tuberculosis / diagnosis*
  • Tuberculosis / microbiology

Substances

  • Culture Media