Dissecting the dynamics of corticothalamic feedback

Henry J Alitto; W Martin Usrey

doi:10.1016/j.neuron.2015.04.016

Dissecting the dynamics of corticothalamic feedback

Neuron. 2015 May 6;86(3):605-7. doi: 10.1016/j.neuron.2015.04.016.

Authors

Henry J Alitto¹, W Martin Usrey²

Affiliations

¹ Center for Neuroscience, University of California, Davis, Davis, CA 95618, USA; Department of Neurobiology, Physiology & Behavior, University of California, Davis, Davis, CA 95616, USA.
² Center for Neuroscience, University of California, Davis, Davis, CA 95618, USA; Department of Neurobiology, Physiology & Behavior, University of California, Davis, Davis, CA 95616, USA; Department of Neurology, University of California, Davis, Sacramento, CA 95817, USA. Electronic address: [email protected].

PMID: 25950627
DOI: 10.1016/j.neuron.2015.04.016

Abstract

The thalamus and neocortex are intimately interconnected via a reciprocal arrangement of feedforward and feedback projections. In this issue of Neuron, Crandall et al. (2015) provide key insight into the functional dynamics of feedback projections and reveal the cellular and circuit mechanisms that underlie a rate-dependent switch in the net influence, suppression versus excitation, that cortex can exert on thalamic relay cells.

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MeSH terms

Animals
Excitatory Postsynaptic Potentials / physiology*
Neural Pathways / physiology*
Somatosensory Cortex / physiology*
Synapses / physiology*
Thalamus / physiology*