Ether lipid deficiency does not cause neutropenia or leukopenia in mice and men

Fabian Dorninger; Christoph Wiesinger; Nancy E Braverman; Sonja Forss-Petter; Johannes Berger

doi:10.1016/j.cmet.2015.04.014

Ether lipid deficiency does not cause neutropenia or leukopenia in mice and men

Cell Metab. 2015 May 5;21(5):650-1. doi: 10.1016/j.cmet.2015.04.014.

Authors

Fabian Dorninger¹, Christoph Wiesinger¹, Nancy E Braverman², Sonja Forss-Petter¹, Johannes Berger³

Affiliations

¹ Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria.
² Department of Human Genetics and Pediatrics, McGill University-Montreal Children's Hospital, Montreal, QC H3Z 2Z3, Canada.
³ Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria. Electronic address: [email protected].

Abstract

In this Letter, Dorninger et al. show that the deficiency in ether lipid biosynthesis alone is not sufficient to induce neutropenia or leukopenia, as has been suggested by a previous report using an inducible knockout mouse model of ether lipid deficiency.

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Fatty Acid Synthases / metabolism*
Humans
Lipids / biosynthesis*
Neutrophils / metabolism*
Phospholipids / metabolism*

Substances

Lipids
Phospholipids
Fatty Acid Synthases

Grants and funding

P 24843/FWF_/Austrian Science Fund FWF/Austria