Forces of Change: Mechanics Underlying Formation of Functional 3D Organ Buds

Paul J Wrighton; Laura L Kiessling

doi:10.1016/j.stem.2015.04.018

Forces of Change: Mechanics Underlying Formation of Functional 3D Organ Buds

Cell Stem Cell. 2015 May 7;16(5):453-4. doi: 10.1016/j.stem.2015.04.018.

Authors

Paul J Wrighton¹, Laura L Kiessling²

Affiliations

¹ Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53792, USA.
² Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53792, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53792, USA. Electronic address: [email protected].

Abstract

3D organ buds that can recapitulate organ function have myriad applications for regenerative and personalized medicine. Here, Takebe et al. (2015) describe a generalized method for organ bud formation, demonstrating that mechanosensitive mesenchymal stem cells drive condensation of heterotypic cell mixtures to create buds from diverse organs.

Publication types

Comment

MeSH terms

Endothelial Cells / physiology*
Humans
Kidney / physiology*
Mesenchymal Stem Cells / physiology*
Pancreas / physiology*
Pluripotent Stem Cells / physiology*
Stem Cells / physiology*

Abstract

Publication types

MeSH terms

Grants and funding