Sesquiterpenes from the fruits of Illicium jiadifengpi and their anti-hepatitis B virus activities

Fitoterapia. 2015 Jul:104:41-4. doi: 10.1016/j.fitote.2015.05.004. Epub 2015 May 9.

Abstract

Two new compounds, 2S-hydroxyl-jiadifenolide (1) and jiadifenlactone acid (2), and eight known compounds were isolated from the fruits of Illicium jiadifengpi. Their structures were analysed using several spectroscopic techniques, including 1D-, 2D-NMR and HR-ESI-MS experiments. The anti-hepatitis B virus (HBV) activities of the isolates were evaluated via HBV transfection of the Hep G2.2.15 cell line. The inhibitory rates of the most active compounds, compounds 4 and 5, on the HBeAg and HBsAg expression were 28.85±3.15% and 17.53±1.81% and 37.93±2.74% and 23.47±9.52% at concentrations of 64.94μM and 61.35μM, respectively.

Keywords: Anti-HBV activity; Illiciaceae; Illicium jiadifengpi; Sesquiterpenes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Fruit / chemistry
  • Hep G2 Cells
  • Hepatitis B virus / drug effects*
  • Humans
  • Illicium / chemistry*
  • Molecular Structure
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / pharmacology*

Substances

  • Antiviral Agents
  • Sesquiterpenes
  • jiadifenlactone acid
  • jiadifenolide