Abstract
Three new decomposition products of valepotriates, valtrals A-C (1-3), and two known products, baldrinal and homobaldrinal, are formed during the isolation procedure of the ethanol extract of the whole plants of Valeriana jatamansi. Their structures were determined by spectroscopic methods including IR, MS, 1D, and 2D NMR experiments. Compounds 1-3 showed selective cytotoxicity against metastatic prostate cancer (PC-3M) and colon cancer (HCT-8) cell lines.
Keywords:
Valeriana jatamansi; cytotoxicity; valepotriates; valtrals A–C.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Colonic Neoplasms / drug therapy
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Drugs, Chinese Herbal / chemistry
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Humans
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Iridoids / chemistry
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Iridoids / isolation & purification*
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Iridoids / pharmacology*
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Male
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Molecular Structure
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Nardostachys
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Nuclear Magnetic Resonance, Biomolecular
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Prostatic Neoplasms / drug therapy
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Valerian / chemistry*
Substances
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Iridoids
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valtral A
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valtral B
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valtral C
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baldrinal
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homobaldrinal