Abstract
The low-density Lipoprotein receptor-related protein (LRP) is a 4544-amino-acid membrane protein which closely resembles the LDL receptor in its arrangement of cysteine-rich motifs. Binding studies have suggested that one function of the molecule is as a receptor for ligands containing apolipoprotein E. We present here the sequence and structure of the promoter region of the LRP. These data show that the LRP contains no sterol regulatory element, and is not down-regulated by sterols like the LDL receptor. This lends further support to the identity of the LRP as a chylomicron remnant receptor.
MeSH terms
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Animals
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Base Sequence
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Chloramphenicol O-Acetyltransferase / metabolism
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Clone Cells
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DNA / genetics
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DNA-Binding Proteins / genetics
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Down-Regulation
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Electrophoresis, Agar Gel
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Gene Expression Regulation
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Humans
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Low Density Lipoprotein Receptor-Related Protein-1
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Luciferases
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Mice
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Molecular Sequence Data
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Promoter Regions, Genetic
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Protein Conformation
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Receptors, Immunologic / genetics*
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Receptors, LDL / genetics*
Substances
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DNA-Binding Proteins
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Low Density Lipoprotein Receptor-Related Protein-1
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Receptors, Immunologic
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Receptors, LDL
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DNA
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Luciferases
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Chloramphenicol O-Acetyltransferase