Abstract
Novel gold-shell nanoparticles (pH-GSNPs) are designed for the first time, which exhibit drug leakage-free behavior in a physiological environment, while achieving rapid drug release and remarkable aggregation for the nanogold interlayer of pH-GSNPs to shift their absorption to far-red and NIR as a photothermal agent in the intracellular microenvironment.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / pharmacology
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Cross-Linking Reagents
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Doxorubicin / pharmacology*
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Drug Carriers*
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Female
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Gold / chemistry*
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Humans
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Hydrogen-Ion Concentration
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Metal Nanoparticles / chemistry*
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Micelles*
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Ovarian Neoplasms / drug therapy*
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Tumor Cells, Cultured
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Tumor Microenvironment / drug effects*
Substances
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Antineoplastic Agents
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Cross-Linking Reagents
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Drug Carriers
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Micelles
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Gold
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Doxorubicin