α-Aminoisobutyric Acid Leads a Fluorescent syn-bimane LASER Probe Across the Blood-brain Barrier

Inbal Lapidot; Danny Baranes; Albert Pinhasov; Gary Gellerman; Amnon Albeck; Flavio Grynszpan; Shimon E Shatzmiller

doi:10.2174/1573406411666150518105010

α-Aminoisobutyric Acid Leads a Fluorescent syn-bimane LASER Probe Across the Blood-brain Barrier

Med Chem. 2016;12(1):48-53. doi: 10.2174/1573406411666150518105010.

Authors

Inbal Lapidot, Danny Baranes, Albert Pinhasov, Gary Gellerman, Amnon Albeck, Flavio Grynszpan¹, Shimon E Shatzmiller²

Affiliations

¹ Department of Biological Chemistry, Ariel University, Ariel 40700, Israel. [email protected].
² Department of Biological Chemistry, Ariel University, Ariel 40700, Israel. [email protected].

PMID: 25981518
DOI: 10.2174/1573406411666150518105010

Abstract

Penetration of the blood brain barrier (BBB) by appropriate fluorescent probes remains a challenge in optical imaging and diagnostics. We designed, synthesized and observed the in vivo BBB penetration of a LASER syn-bimane probe. Results demonstrate that the Aib transporter unit in our probe may lead a fluorescent bimanyl moiety across the BBB.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aminoisobutyric Acids / chemical synthesis
Aminoisobutyric Acids / pharmacokinetics*
Animals
Azabicyclo Compounds / chemical synthesis
Azabicyclo Compounds / pharmacokinetics*
Blood-Brain Barrier / metabolism*
Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis
Bridged Bicyclo Compounds, Heterocyclic / pharmacokinetics*
Fluorescent Dyes / chemical synthesis
Fluorescent Dyes / pharmacokinetics*
Male
Mice
Microscopy, Fluorescence
Tissue Distribution

Substances

Aminoisobutyric Acids
Azabicyclo Compounds
Bridged Bicyclo Compounds, Heterocyclic
Fluorescent Dyes
bimanes